Endocrine Abstracts

Little is known about the molecules that contribute to tumor growth in epithelial ovarian cancer (EOC) that remain the most lethal gynecological neoplasm. Glucocorticoid-Induced Leucine Zipper (GILZ), a leucine zipper protein of 17 kDa, is frequently detected in epithelial tissues with a hormonal background. We detected GILZ in EOC1 and we further demonstrated that this factor which expression is enhanced by estradiol (E2), activates tumor cell proliferat...

Loss of gonadotropin-releasing hormone (GnRH) and cognitive deficits have recently been demonstrated by our group in conditions including Down syndrome and Alzhiemer’s disease. In some patients with COVID-19, olfactory and cognitive alterations persist, and persistent hypotestosteronemia in SARS-CoV-2-infected men could be a consequence of deficient GnRH. To understand whether neuroinvasion of GnRH system by SARS-CoV-2 could explain some post-COVID symptoms and thus resul...